Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363915 | 0.82 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2ALDH1A1TDP1TPMT | |
| SCHEMBL1185665 | 0.82 | TSHR (0.48) | KMT2ASMN1; SMN2ALDH1A1TDP1NPSR1 | |
| SCHEMBL7284626 | 0.78 | TDP1 (0.42) | KMT2AALDH1A1TDP1NPSR1MAPT | |
| SCHEMBL6232015 | 0.77 | GPR35 (0.42) | ALDH1A1NPSR1TSHRMAPTHTT | |
| SCHEMBL19782588 | 0.76 | TDP1 (0.48) | KMT2ASMN1; SMN2ALDH1A1TDP1MAPT | |
| SCHEMBL23273444 | 0.75 | NPSR1 (0.36) | ALDH1A1TDP1NPSR1TSHRMAPT | |
| SCHEMBL5390806 | 0.74 | NPSR1 (0.35) | KMT2ASMN1; SMN2GSTP1GSTM2ALDH1A1 | |
| SCHEMBL17374964 | 0.74 | TDP1 (0.44) | KMT2AALDH1A1TDP1NPSR1TSHR | |
| SCHEMBL31150407 | 0.73 | ALDH1A1 (0.53) | KMT2ASMN1; SMN2ALDH1A1TDP1NPSR1 | |
| SCHEMBL4748764 | 0.73 | ALDH1A1 (0.53) | KMT2ASMN1; SMN2ALDH1A1TDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632019-B1 | Acylureas | ZENECA LTD (GB) | 1997-09-24 | — | — | EP | disclosed |
| US-5576334-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1996-11-19 | — | — | US | disclosed |
| EP-0632019-A1 | Acylureas | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |