Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 9/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13482971 | 1.00 | ADRB3 (0.53) | ADRB3ADRB1ADRB2GLAL3MBTL1 | |
| SCHEMBL30088535 | 1.00 | ADRB3 (0.53) | ADRB3ADRB1ADRB2GLAL3MBTL1 | |
| SCHEMBL282281 | 0.85 | ADRB3 (0.46) | ADRB3ADRB1ADRB2GLAL3MBTL1 | |
| SCHEMBL8770902 | 0.84 | L3MBTL1 (0.43) | ADRB3ADRB1ADRB2GLAL3MBTL1 | |
| SCHEMBL8770904 | 0.83 | L3MBTL1 (0.46) | ADRB3ADRB1ADRB2GLAL3MBTL1 | |
| SCHEMBL24036585 | 0.83 | PNP (0.47) | ADRB3ADRB1ADRB2GLAPNP | |
| SCHEMBL4938396 | 0.83 | PNP (0.47) | ADRB3ADRB1ADRB2GLAPNP | |
| SCHEMBL12647202 | 0.83 | PNP (0.45) | ADRB3ADRB1ADRB2GLAPNP | |
| SCHEMBL13882102 | 0.83 | HIF1A (0.57) | ADRB3ADRB1ADRB2L3MBTL1ADRA1A | |
| SCHEMBL16788643 | 0.82 | L3MBTL1 (0.49) | ADRB3ADRB1ADRB2L3MBTL1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115537405-B | Ketoreductase and application thereof in preparation of (S) -1- (3-chlorophenyl) -1, 3-propanediol | 尚科生物医药（上海）有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-115537405-A | Ketoreductase and application thereof in preparation of (S) -1- (3-chlorphenyl) -1, 3-propylene glycol | 尚科生物医药（上海）有限公司 | 2022-12-30 | — | — | CN | disclosed |
| EP-3130593-B1 | PHENANTHROLINE PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | XIAMEN BERYL THERAPEUTICS INC (CN) | 2020-09-23 | — | — | EP | disclosed |
| CN-110433165-A | The combination and its application method of AKT and mek inhibitor compound | GENENTECH INC | 2019-11-12 | — | — | CN | disclosed |
| EP-3130593-A1 | PHENANTHROLINE PHOSPHONIC ACID DERIVATIVE AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Beryl Therapeutics, Inc. (CN) | 2017-02-15 | — | — | EP | disclosed |
| CN-103874689-B | combinations of AKT inhibitor compounds and vemurafenib and methods of use | GENENTECH, INC. (US) | 2016-04-27 | — | — | CN | disclosed |
| CN-104586861-A | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND ABIRATERONE, AND METHODS OF USE | GENENTECH INC | 2015-05-06 | — | — | CN | disclosed |
| CN-103874689-A | combinations of AKT inhibitor compounds and vemurafenib and methods of use | GENENTECH INC | 2014-06-18 | — | — | CN | disclosed |
| CN-103857395-A | Combinations of AKT inhibitor compounds and abiraterone and methods of use | GENENTECH INC | 2014-06-11 | — | — | CN | disclosed |
| CN-103841976-A | Combinations of AKT and MEK inhibitor compounds and methods of use thereof | GENENTECH INC | 2014-06-04 | — | — | CN | disclosed |
| CN-103841975-A | COMBINATIONS OF AKT INHIBITOR COMPOUNDS AND VEMURAFENIB, AND METHODS OF USE | GENENTECH INC | 2014-06-04 | — | — | CN | disclosed |
| CN-103288753-A | Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC | 2013-09-11 | — | — | CN | disclosed |
| CN-101959887-B | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2013-07-31 | — | — | CN | disclosed |
| CN-101631778-B | Cyclopenta [ D ] pyrimidines as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC | 2013-05-08 | — | — | CN | disclosed |
| CN-101965347-B | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2013-01-02 | — | — | CN | disclosed |
| CN-101965347-A | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2011-02-02 | — | — | CN | disclosed |
| CN-101959887-A | Pyrrolopyridine as kinase inhibitor | ARRAY BIOPHARMA INC | 2011-01-26 | — | — | CN | disclosed |
| EP-0451668-B1 | Process for the production of optically active alkyl 3-aryl-3-hydroxypropionates | CHISSO CORP (JP) | 1997-08-13 | — | — | EP | disclosed |
| US-5202457-A | Enzyme catalyzed transesterification, resolution of optical active alkyl 3-aryl-3-hydroxypropionate | CHISSO CORPORATION (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0451668-A2 | Optically active alkyl 3-aryl-3-hydroxypropionates and a method for producing thereof | CHISSO CORPORATION (JP) | 1991-10-16 | — | — | EP | disclosed |