SCHEMBL8771228

SCHEMBL8771228

Nc1ccc(C(=O)Nc2ccc(Oc3ccc(NC(=O)c4ccc(N)cc4)cc3)cc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.79
MEN1 O00255 1/20 0.79
LMNA P02545 1/20 0.79
PKM P14618 1/20 0.79
APEX1 P27695 1/20 0.79
KMT2A Q03164 1/20 0.79
TDP1 Q9NUW8 1/20 0.79
NPC1 O15118 3/20 0.69
RAB9A P51151 3/20 0.69
TP53 P04637 2/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
BRAF P15056 4/20 0.68
HDAC1 Q13547 4/20 0.68
HDAC3 O15379 1/20 0.68
HDAC4 P56524 1/20 0.68
HDAC7 Q8WUI4 1/20 0.68
HDAC2 Q92769 1/20 0.68
HDAC10 Q969S8 1/20 0.68
HDAC11 Q96DB2 1/20 0.68
HDAC8 Q9BY41 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22192221 1.00 POLB (0.79) POLBMEN1LMNAPKMAPEX1
SCHEMBL9812466 1.00 POLB (0.79) POLBMEN1LMNAPKMAPEX1
SCHEMBL22444366 1.00 POLB (0.79) POLBMEN1LMNAPKMAPEX1
SCHEMBL22694283 1.00 POLB (0.79) POLBMEN1LMNAPKMAPEX1
SCHEMBL17198004 0.92 POLB (0.67) POLBMEN1LMNAPKMAPEX1
SCHEMBL28850376 0.92 PGR (0.71) POLBMEN1LMNAPKMAPEX1
SCHEMBL11650148 0.92 PGR (0.81) POLBMEN1LMNAPKMAPEX1
SCHEMBL2128727 0.89 POLB (1.00) POLBMEN1LMNAPKMAPEX1
SCHEMBL137276 0.89 POLB (1.00) POLBMEN1LMNAPKMAPEX1
SCHEMBL1353478 0.89 POLB (1.00) POLBMEN1LMNAPKMAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025121334-A1 POLYIMIDE RESIN 三菱瓦斯化学株式会社 2025-06-12 WO disclosed
WO-2025121336-A1 POLYIMIDE RESIN 三菱瓦斯化学株式会社 2025-06-12 WO disclosed
WO-2025121335-A1 METHOD FOR PRODUCING POLYIMIDE VARNISH 三菱瓦斯化学株式会社 2025-06-12 WO disclosed
US-9622991-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2017-04-18 US disclosed
US-9144557-B2 Hematopoietic growth factor mimetic small molecule compounds and their uses LIGAND PHARMACEUTICALS INC. (US) 2015-09-29 US disclosed
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2015-09-10 US disclosed
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-08-28 US disclosed
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2012-11-22 US disclosed
WO-2012068406-A2 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS LIGAND PHARMACEUTICALS INCORPORATED (US) 2012-05-24 WO disclosed
WO-2011046954-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES LIGAND PHARMACEUTICALS INC. (US) 2011-04-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243324-A1 USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS HGF, EPOR, MPL POLB 3018/4885MEN1 1370/4885LMNA 4611/4885
US-20150252043-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF POLB 3224/4885MEN1 1395/4885LMNA 3995/4885
US-20120295904-A1 HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES MPL, CSF3R, HGF POLB 3224/4885MEN1 1395/4885LMNA 3995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.