Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 15/20 | 0.55 |
| ▸ | RARA | P10276 | 14/20 | 0.55 |
| ▸ | RARG | P13631 | 14/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771766 | 0.79 | PTGS2 (0.48) | PTGS2PTGDR2LMNAHPGDPDE4D | |
| SCHEMBL6261635 | 0.79 | RARB (0.57) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL8771791 | 0.75 | RARB (0.54) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL20636833 | 0.74 | RARB (0.65) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL12365355 | 0.73 | RARB (0.67) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL5847717 | 0.71 | PTGS2 (0.59) | RARBRARARARGRXRAPTGS2 | |
| SCHEMBL8026323 | 0.71 | RARB (0.71) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL6210444 | 0.70 | RARA (1.00) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL20636874 | 0.70 | RARB (0.66) | RARBRARARARGRXRANR2E1 | |
| SCHEMBL20848217 | 0.70 | RARA (0.66) | RARBRARARARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661259-B1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL MYERS SQUIBB CO (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5648385-A | TREATING RHEUMATOID ARTHRITIS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-15 | — | — | US | disclosed |
| US-5618839-A | Retinoid-like compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-04-08 | — | — | US | disclosed |
| CN-1144217-A | Retinoid-like compounds | BRISTOL MYERS SQUIBB CO (US) | 1997-03-05 | — | — | CN | disclosed |
| EP-0661259-A1 | Substituted (5,6)-dihydronaphthalenyl compounds having retinoid-like activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-07-05 | — | — | EP | disclosed |