Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962783 | 1.00 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL8772192 | 0.87 | P2RY14 (0.40) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL1961020 | 0.87 | P2RY14 (0.40) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL6113620 | 0.84 | P2RY14 (0.40) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL6113618 | 0.84 | P2RY14 (0.40) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL1959761 | 0.79 | ABCC1 (0.34) | ALDH1A1LMNAMAPTDGAT1MCHR1 | |
| SCHEMBL2013699 | 0.79 | ABCC1 (0.34) | ALDH1A1LMNAMAPTDGAT1MCHR1 | |
| SCHEMBL2018115 | 0.79 | P2RY14 (0.39) | ALDH1A1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL9967382 | 0.77 | CXCR1 (0.33) | LMNAMAPTDGAT1MCHR1 | |
| SCHEMBL1333746 | 0.77 | CXCR1 (0.33) | LMNAMAPTDGAT1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651913-B1 | INDENO-FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL INC (US) | 2017-04-19 | — | — | EP | disclosed |
| US-9309455-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-9309455-B2 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140166948-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL LIMITED (IE) | 2014-06-19 | — | — | US | disclosed |
| US-20140166948-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL LIMITED (IE) | 2014-06-19 | — | — | US | disclosed |
| WO-2012082381-A1 | INDENO- FUSED RING COMPOUNDS HAVING PHOTOCHROMIC PROPERTIES | TRANSITIONS OPTICAL, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2012-05-24 | — | — | US | disclosed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110140056-A1 | Indeno-fused ring compounds | TRANSITIONS OPTICAL, INC. (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110140056-A1 | Indeno-fused ring compounds | CRY2, SQOR, INTS6 | ALDH1A1 498/4885LMNA 1680/4885MAPT 2624/4885 |
| US-20120126185-A1 | INDENO-FUSED RING COMPOUNDS | CRY2, SQOR, INTS6 | ALDH1A1 498/4885LMNA 1680/4885MAPT 2624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.