Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772449 | 0.87 | CYP1A2 (0.42) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL8443289 | 0.84 | POLB (0.42) | MAPTALDH1A1LMNAHTTCYP3A4 | |
| SCHEMBL8439355 | 0.80 | GSK3A (0.44) | ALDH1A1MEN1KMT2ATSHRHTT | |
| SCHEMBL8772476 | 0.77 | ALDH1A1 (0.46) | KCNA5KCNH2MAPTALDH1A1TSHR | |
| SCHEMBL8772498 | 0.76 | HTT (0.39) | KCNA5KCNH2MAPTALDH1A1MEN1 | |
| SCHEMBL8772454 | 0.76 | POLB (0.42) | ALDH1A1MEN1KMT2ALMNAGAA | |
| SCHEMBL8441167 | 0.75 | ALDH1A1 (0.48) | KCNA5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL8442958 | 0.71 | MAPT (0.47) | MAPTMEN1KMT2ALMNA | |
| SCHEMBL31175413 | 0.68 | GSK3A (0.53) | ALDH1A1HTTGAA | |
| SCHEMBL8772552 | 0.66 | KMT2A (0.41) | KCNA5KCNH2ALDH1A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |