Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623161 | 0.93 | GSK3B (0.39) | GSK3AGSK3BTDP1L3MBTL1SIGMAR1 | |
| SCHEMBL8772454 | 0.93 | POLB (0.42) | GSK3AGSK3BTDP1L3MBTL1SIGMAR1 | |
| SCHEMBL8772449 | 0.93 | CYP1A2 (0.42) | GSK3AGSK3BTDP1L3MBTL1GAA | |
| SCHEMBL8552263 | 0.86 | HRH1 (0.39) | NAAASMN1; SMN2ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8104154 | 0.84 | FAAH (0.44) | GSK3AGSK3BTDP1L3MBTL1SIGMAR1 | |
| SCHEMBL8442243 | 0.81 | TRPV1 (0.49) | L3MBTL1GAASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL8772533 | 0.80 | KCNA5 (0.42) | GAAHTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8550864 | 0.78 | HDAC1 (0.39) | MEN1KMT2A | |
| SCHEMBL8440706 | 0.77 | HMOX1 (0.40) | TDP1L3MBTL1GAAMAPK1HTT | |
| SCHEMBL8772491 | 0.77 | HTR2A (0.42) | GSK3AGSK3BTDP1L3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| US-5534535-A | ANTIVIRAL ANALOGS WITH SUBSTITUTED BENZIMIDAZOLE BASE | BURROUGHS WELLCOME CO. (US) | 1996-07-09 | — | — | US | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |
| EP-0630368-A1 | ANTIVIRAL NUCLEOSIDE ANALOGUES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018009-A1 | ANTIVIRAL NUCLEOSIDE ANALOGUES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-16 | — | — | WO | disclosed |