Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442979 | 0.93 | GSK3A (0.46) | GSK3AGSK3BSIGMAR1CCR3TDP1 | |
| SCHEMBL8440233 | 0.92 | FAAH (0.44) | GSK3AGSK3BSIGMAR1CCR3TDP1 | |
| SCHEMBL8552527 | 0.89 | HRH3 (0.41) | POLBSIGMAR1 | |
| SCHEMBL8772441 | 0.88 | GSK3A (0.40) | GSK3AGSK3BSIGMAR1ALDH1A1TDP1 | |
| SCHEMBL8438564 | 0.88 | GSK3A (0.43) | GSK3AGSK3BSIGMAR1L3MBTL1FAAH | |
| SCHEMBL8438577 | 0.82 | PLAAT3 (0.47) | POLBALDH1A1L3MBTL1LMNA | |
| SCHEMBL8439155 | 0.82 | PLAAT3 (0.47) | POLBALDH1A1L3MBTL1LMNA | |
| SCHEMBL8438842 | 0.82 | PLAAT3 (0.47) | POLBALDH1A1L3MBTL1LMNA | |
| SCHEMBL8440368 | 0.82 | PLAAT3 (0.47) | POLBALDH1A1L3MBTL1LMNA | |
| SCHEMBL8443375 | 0.82 | GAA (0.44) | GSK3AGSK3BALDH1A1L3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |