Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8772720 | 0.98 | MEN1 (0.39) | MEN1KMT2ANPBWR1MCHR1FDFT1 | |
| SCHEMBL8772588 | 0.83 | PTGDR (0.39) | MEN1KMT2AFDFT1ALDH1A1MAPT | |
| SCHEMBL8422017 | 0.83 | FDFT1 (0.39) | MEN1KMT2AFDFT1ALDH1A1MAPT | |
| SCHEMBL8423284 | 0.82 | FDFT1 (0.41) | FDFT1ALDH1A1KDM4EGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL8421585 | 0.80 | FDFT1 (0.41) | KMT2AFDFT1MAPTKDM4EGABRA1 | |
| SCHEMBL8772595 | 0.79 | FDFT1 (0.38) | MEN1KMT2AFDFT1ALDH1A1MAPT | |
| SCHEMBL8772704 | 0.79 | FDFT1 (0.37) | MEN1FDFT1PTGDRPTGDR2 | |
| SCHEMBL8772725 | 0.79 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL8772603 | 0.78 | FDFT1 (0.45) | MEN1KMT2AFDFT1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8772570 | 0.78 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |