Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542210 | 0.84 | CA1 (0.57) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL31588071 | 0.82 | PKM (0.60) | HTTALDH1A1HPGDGABRA1POLB | |
| SCHEMBL1515872 | 0.81 | CA12 (0.62) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL8772573 | 0.80 | CA12 (0.60) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL31588508 | 0.79 | PKM (0.57) | HTTALDH1A1HPGDGABRA1POLB | |
| SCHEMBL1092424 | 0.79 | HTT (0.71) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL4943834 | 0.78 | HTT (0.61) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL8465492 | 0.78 | HTT (0.61) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL8419839 | 0.78 | HDAC6 (0.50) | HTTALDH1A1HPGDLMNAGABRA1 | |
| SCHEMBL9550443 | 0.77 | HTT (0.60) | HTTALDH1A1HPGDLMNAGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |