Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8026331 | 0.87 | HIF1A (0.33) | HTR2CBACE1HIF1AEPAS1CMA1 | |
| SCHEMBL9485242 | 0.84 | KDM1A (0.30) | KDM1A | |
| SCHEMBL30659806 | 0.78 | AKR1B1 (0.33) | KDM1AHTR2CHIF1AEPAS1 | |
| SCHEMBL8031290 | 0.77 | TDP2 (0.36) | HIF1AEPAS1 | |
| SCHEMBL7604066 | 0.75 | SIGMAR1 (0.40) | HTR2C | |
| SCHEMBL8170079 | 0.73 | HIF1A (0.33) | HIF1AEPAS1 | |
| SCHEMBL30320303 | 0.72 | HIF1A (0.33) | HIF1AEPAS1 | |
| SCHEMBL4369386 | 0.72 | HIF1A (0.33) | HIF1AEPAS1 | |
| SCHEMBL869051 | 0.72 | IDO1 (0.34) | — | |
| SCHEMBL26105726 | 0.72 | NQO1 (0.31) | HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |
| EP-0800517-A1 | ACETYLENES DISUBSTITUTED WITH A 5 OR 8 SUBSTITUTED TETRAHYDRONAPHTHYL OR DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUPS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan (US) | 1997-10-15 | — | — | EP | disclosed |