Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 11/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.38 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.37 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.37 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773722 | 0.90 | RARB (0.53) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773674 | 0.90 | CYP26A1 (0.41) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773686 | 0.90 | RARB (0.53) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773679 | 0.90 | RARB (0.53) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773690 | 0.90 | RARB (0.53) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773636 | 0.89 | RARB (0.42) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL7884597 | 0.81 | RARA (0.47) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL7884594 | 0.81 | RARA (0.47) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773653 | 0.74 | RXRA (0.43) | CYP26A1MEN1CYP3A4RARARARB | |
| SCHEMBL8773715 | 0.74 | RXRA (0.43) | CYP26A1MEN1CYP3A4RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728739-B1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CIRD GALDERMA (FR) | 1997-11-05 | — | — | EP | claimed |
| EP-0728739-A1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-08-28 | — | — | EP | claimed |
| EP-0728739-B1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CIRD GALDERMA (FR) | 1997-11-05 | — | — | EP | disclosed |
| EP-0728739-A1 | Biaromatic amide derivatives, pharmaceutical and cosmetic compositions containing them and their utilisations | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-08-28 | — | — | EP | disclosed |