Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 10/20 | 0.70 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635096 | 0.87 | LTA4H (0.60) | LTA4HS1PR5S1PR1 | |
| SCHEMBL19535305 | 0.87 | LTA4H (0.60) | LTA4HS1PR5S1PR1 | |
| SCHEMBL8773751 | 0.84 | LTA4H (0.68) | LTA4HSIGMAR1 | |
| SCHEMBL7140105 | 0.82 | LTA4H (0.97) | LTA4HSIGMAR1RAB9ASMN1; SMN2 | |
| SCHEMBL7139511 | 0.82 | LTA4H (0.97) | LTA4HSIGMAR1RAB9ASMN1; SMN2 | |
| SCHEMBL8773749 | 0.78 | LTA4H (0.49) | LTA4HS1PR5S1PR1 | |
| SCHEMBL8639100 | 0.78 | LTA4H (0.54) | LTA4HS1PR5S1PR1NPC1RAB9A | |
| SCHEMBL1002589 | 0.78 | LTA4H (1.00) | LTA4H | |
| SCHEMBL7404320 | 0.76 | DRD4 (0.64) | LTA4HSIGMAR1 | |
| SCHEMBL8773741 | 0.74 | LTA4H (0.52) | LTA4HS1PR5S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | claimed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | claimed |
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |