Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773765 | 0.78 | LTA4H (0.70) | LTA4HS1PR5S1PR1NPC1RAB9A | |
| SCHEMBL3635096 | 0.77 | LTA4H (0.60) | LTA4HS1PR5S1PR1 | |
| SCHEMBL19535305 | 0.77 | LTA4H (0.60) | LTA4HS1PR5S1PR1 | |
| SCHEMBL8644136 | 0.73 | LTA4H (0.48) | LTA4HSMN1; SMN2PPARGPPARAL3MBTL1 | |
| SCHEMBL8773741 | 0.72 | LTA4H (0.52) | LTA4HS1PR5S1PR1L3MBTL1 | |
| SCHEMBL12130576 | 0.72 | SLC6A3 (0.48) | LTA4H | |
| SCHEMBL1002589 | 0.70 | LTA4H (1.00) | LTA4H | |
| SCHEMBL8641938 | 0.69 | LTA4H (0.52) | LTA4HS1PR5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8773749 | 0.69 | LTA4H (0.49) | LTA4HS1PR5S1PR1TSHR | |
| SCHEMBL8644161 | 0.68 | LTA4H (0.86) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |