Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3635096 | 0.91 | LTA4H (0.60) | LTA4HS1PR5SLC18A3S1PR1 | |
| SCHEMBL19535305 | 0.91 | LTA4H (0.60) | LTA4HS1PR5SLC18A3S1PR1 | |
| SCHEMBL8773741 | 0.79 | LTA4H (0.52) | LTA4HS1PR5S1PR1 | |
| SCHEMBL8773765 | 0.78 | LTA4H (0.70) | LTA4HS1PR5S1PR1 | |
| SCHEMBL7138681 | 0.76 | LTA4H (0.82) | LTA4HS1PR5 | |
| SCHEMBL8773785 | 0.74 | LTA4H (0.44) | LTA4HS1PR5SLC18A3S1PR1 | |
| SCHEMBL7138408 | 0.74 | LTA4H (0.71) | LTA4HTSHR | |
| SCHEMBL5752956 | 0.73 | KDM4E (0.54) | — | |
| SCHEMBL5751377 | 0.72 | SIGMAR1 (0.45) | TSHR | |
| SCHEMBL6994717 | 0.71 | HTR2A (0.64) | S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | claimed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | claimed |
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |