SCHEMBL8773965

SCHEMBL8773965

O=C(O)CN1C(=O)C(N2C(=O)c3ccccc3C2=O)N=C(C2CCCCC2)c2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 11/20 0.45
CCKAR P32238 5/20 0.45
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43
TRPA1 O75762 2/20 0.43
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
POLB P06746 1/20 0.40
BDKRB1 P46663 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8773971 1.00 CCKBR (0.45) CCKBRCCKARCA12CA9TRPA1
SCHEMBL8773950 0.85 CCKBR (0.42) CCKBRCCKARTRPA1ALDH1A1GAA
SCHEMBL2687501 0.84 CCKBR (0.47) CCKBRCCKARTRPA1BDKRB1
SCHEMBL30320119 0.84 CCKBR (0.47) CCKBRCCKARTRPA1BDKRB1
SCHEMBL12893383 0.84 CCKBR (0.49) CCKBRCCKARTRPA1BDKRB1
SCHEMBL8537959 0.81 ALDH1A1 (0.48) CCKBRCCKARALDH1A1BDKRB1
SCHEMBL8537963 0.81 ALDH1A1 (0.48) CCKBRCCKARALDH1A1BDKRB1
SCHEMBL30467339 0.76 CCKBR (0.41) CCKBRCCKARALDH1A1GAABDKRB1
SCHEMBL8533711 0.74 CCKBR (0.36) CCKBRCCKARTRPA1ALDH1A1BDKRB1
SCHEMBL8774054 0.70 CCKBR (0.44) CCKBRCCKARALDH1A1BDKRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804425-A2 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-11-05 EP disclosed
WO-1996004254-A2 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-02-15 WO disclosed