Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.49 |
| ▸ | RARA | P10276 | 2/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774250 | 0.96 | RARB (0.44) | RARBRARARARGHSD17B10TSHR | |
| SCHEMBL8774823 | 0.96 | HTR2A (0.46) | RARBRARARARGHSD17B10HTR2A | |
| SCHEMBL8774041 | 0.94 | HTR2A (0.49) | RARBRARARARGHSD17B10HTR2A | |
| SCHEMBL8774498 | 0.91 | HTR2A (0.40) | RARBRARARARGHSD17B10TSHR | |
| SCHEMBL8774334 | 0.90 | NPC1 (0.40) | RARBRARARARGHSD17B10MAPT | |
| SCHEMBL8774330 | 0.87 | CYP3A4 (0.43) | RARBRARARARGALDH1A1MEN1 | |
| SCHEMBL8774513 | 0.87 | TAAR1 (0.39) | RARBRARARARGRAB9AGAA | |
| SCHEMBL8774925 | 0.87 | CYP2D6 (0.46) | RARBRARAHSD17B10ALDH1A1MEN1 | |
| SCHEMBL8774829 | 0.85 | RAB9A (0.36) | HSD17B10ALDH1A1MAPTRAB9AGAA | |
| SCHEMBL8774890 | 0.84 | RARB (0.50) | RARBRARARARGHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |