SCHEMBL8774059

SCHEMBL8774059

CCCCCCCCOc1ccc(-c2ccc(O)c(F)c2)cc1F

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 10/20 0.53
FAAH O00519 2/20 0.53
CNR1 P21554 2/20 0.53
THRA P10827 1/20 0.50
THRB P10828 1/20 0.50
ESR1 P03372 3/20 0.48
PTPN11 Q06124 2/20 0.48
S1PR1 P21453 2/20 0.46
S1PR3 Q99500 2/20 0.46
S1PR2 O95136 1/20 0.46
LPAR2 Q9HBW0 1/20 0.46
ESR2 Q92731 1/20 0.46
S1PR4 O95977 1/20 0.46
S1PR5 Q9H228 1/20 0.46
SMPD1 P17405 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8774258 1.00 MGLL (0.53) MGLLFAAHCNR1THRATHRB
SCHEMBL8774006 1.00 MGLL (0.53) MGLLFAAHCNR1THRATHRB
SCHEMBL8773996 1.00 MGLL (0.53) MGLLFAAHCNR1THRATHRB
SCHEMBL9477667 0.91 THRA (0.53) MGLLTHRATHRBPTPN11S1PR1
SCHEMBL9484989 0.91 THRA (0.53) MGLLTHRATHRBPTPN11S1PR1
SCHEMBL9483389 0.91 THRA (0.53) MGLLTHRATHRBPTPN11S1PR1
SCHEMBL9484995 0.91 THRA (0.53) MGLLTHRATHRBPTPN11S1PR1
SCHEMBL9484258 0.91 THRA (0.53) MGLLTHRATHRBPTPN11S1PR1
SCHEMBL6249403 0.90 MGLL (0.46) MGLLFAAHCNR1THRATHRB
SCHEMBL7861063 0.89 ESR1 (0.49) MGLLFAAHCNR1ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0496896-B1 CYCLOBUTANECARBOXYLIC ACID DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME KANTO KAGAKU (JP) 1997-11-05 EP disclosed
US-5545747-A STABLE FERROELECTRIC LIQUID CRYSTALLINE COMPOUNDS KANTO KAGAKU KABUSHIKI KAISHA (JP) 1996-08-13 US disclosed
EP-0496896-A1 CYCLOBUTANECARBOXYLIC ACID DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME KANTO KAGAKU KABUSHIKI KAISHA (JP) 1992-08-05 EP disclosed