Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484989 | 1.00 | THRA (0.53) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9484258 | 1.00 | THRA (0.53) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9484995 | 1.00 | THRA (0.53) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9483389 | 1.00 | THRA (0.53) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9484097 | 0.98 | THRA (0.52) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9399556 | 0.98 | THRA (0.52) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9484969 | 0.98 | THRA (0.51) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9486073 | 0.97 | THRA (0.51) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9483702 | 0.95 | L3MBTL1 (0.54) | THRATHRBPTPN11S1PR1S1PR3 | |
| SCHEMBL9483679 | 0.94 | MGLL (0.55) | THRATHRBPTPN11S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182047-A | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1993-01-26 | — | — | US | disclosed |
| EP-0368975-B1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1992-12-16 | — | — | EP | disclosed |
| EP-0368975-A1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989012039-A1 | FLUORINATED BIPHENYLDIOLE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-12-14 | — | — | WO | disclosed |