Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 6/20 | 0.36 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774803 | 1.00 | PANK3 (0.36) | PANK3USP25KDM5AKDM4CDRD2 | |
| SCHEMBL8774422 | 0.92 | PANK3 (0.35) | PANK3USP25KDM5AKDM4CDRD2 | |
| SCHEMBL8774430 | 0.92 | PANK3 (0.35) | PANK3USP25KDM5AKDM4CDRD2 | |
| SCHEMBL8774341 | 0.91 | SPHK1 (0.39) | DRD2 | |
| SCHEMBL8774331 | 0.91 | SPHK1 (0.39) | DRD2 | |
| SCHEMBL8774094 | 0.89 | PANK3 (0.38) | PANK3USP25KDM5AKDM4COPRL1 | |
| SCHEMBL8774102 | 0.89 | PANK3 (0.38) | PANK3USP25KDM5AKDM4COPRL1 | |
| SCHEMBL9156283 | 0.86 | PANK3 (0.34) | PANK3USP25KDM5AKDM4CDRD2 | |
| SCHEMBL9156280 | 0.86 | PANK3 (0.34) | PANK3USP25KDM5AKDM4CDRD2 | |
| SCHEMBL8775016 | 0.86 | SPHK1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |