Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 9/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774122 | 1.00 | DGAT1 (0.39) | DGAT1GRIN2BGRIN1ALDH1A1ALOX5AP | |
| SCHEMBL8774544 | 0.90 | CYP2C9 (0.45) | DGAT1GRIN2BGRIN1ALDH1A1GPR55 | |
| SCHEMBL8774551 | 0.90 | CYP2C9 (0.45) | DGAT1GRIN2BGRIN1ALDH1A1GPR55 | |
| SCHEMBL8774502 | 0.87 | CYP2C9 (0.38) | DGAT1GRIN2BGRIN1ALDH1A1GPR55 | |
| SCHEMBL8774509 | 0.87 | CYP2C9 (0.38) | DGAT1GRIN2BGRIN1ALDH1A1GPR55 | |
| SCHEMBL8774946 | 0.86 | MAPT (0.38) | DGAT1GRIN2BGRIN1ALDH1A1JAK2 | |
| SCHEMBL8774956 | 0.86 | MAPT (0.38) | DGAT1GRIN2BGRIN1ALDH1A1JAK2 | |
| SCHEMBL8774585 | 0.86 | ALOX5AP (0.42) | GRIN2BGRIN1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL8774577 | 0.86 | ALOX5AP (0.42) | GRIN2BGRIN1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL8774057 | 0.85 | MAPT (0.39) | DGAT1ALDH1A1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |