Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877845 | 0.81 | F10 (0.35) | F10POLB | |
| SCHEMBL877739 | 0.80 | KDM4A (0.31) | POLBDRD2 | |
| SCHEMBL878301 | 0.77 | CCR5 (0.35) | F10MCHR1CCR5POLBDRD2 | |
| SCHEMBL878508 | 0.77 | F10 (0.34) | F10MCHR1CCR5POLBDRD2 | |
| SCHEMBL877632 | 0.77 | HRH4 (0.31) | POLB | |
| SCHEMBL876437 | 0.76 | F10 (0.33) | F10MCHR1CCR5POLBJAK2 | |
| SCHEMBL876715 | 0.76 | CCR5 (0.37) | F10MCHR1CCR5POLBJAK2 | |
| SCHEMBL878098 | 0.75 | HRH4 (0.32) | POLB | |
| SCHEMBL877667 | 0.75 | ACACB (0.32) | POLB | |
| SCHEMBL785119 | 0.74 | MCHR1 (0.44) | F10MCHR1CCR5POLBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | claimed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |