Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774204 | 1.00 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774209 | 1.00 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774260 | 1.00 | MAPT (0.37) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774205 | 0.99 | AKR1C2 (0.36) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774201 | 0.99 | AKR1C2 (0.36) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774328 | 0.95 | GPR84 (0.38) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774323 | 0.95 | GPR84 (0.38) | MAPTRAB9ASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL8774303 | 0.90 | GPR84 (0.36) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8774299 | 0.90 | GPR84 (0.36) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL8774904 | 0.88 | GPR84 (0.36) | MEN1KMT2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |