SCHEMBL877430

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL882886	0.94	EGFR (0.44)	ERBB2EGFRERBB4ITKROCK2
	SCHEMBL10220824	0.92	EGFR (0.44)	ERBB2EGFRERBB4ITKROCK2
	SCHEMBL877021	0.91	ERBB2 (0.51)	ERBB2EGFRERBB4ROCK2ABCG2
	SCHEMBL877683	0.91	EGFR (0.44)	ERBB2EGFRERBB4ITKROCK2
	SCHEMBL877391	0.90	ROCK2 (0.51)	ERBB2EGFRERBB4ROCK2ROCK1
	SCHEMBL877936	0.89	ROCK2 (0.47)	ERBB2EGFRERBB4ITKROCK2
	SCHEMBL877935	0.89	ROCK2 (0.56)	ERBB2EGFRERBB4ITKROCK2
	SCHEMBL877247	0.89	EGFR (0.44)	ERBB2EGFRITKROCK2ROCK1
	SCHEMBL877114	0.89	ABCG2 (0.45)	ERBB2EGFRITKROCK2ROCK1
	SCHEMBL877501	0.88	ROCK2 (0.51)	EGFRROCK2ROCK1CHEK2PAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.