SCHEMBL877936

SCHEMBL877936

CCCCNc1cccc(-c2nc(Nc3ccc4c(cnn4C(=O)OC(C)(C)C)c3)c3cc(OCCCl)c(OC)cc3n2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 5/20 0.47
EGFR P00533 4/20 0.44
ITK Q08881 1/20 0.44
ERBB2 P04626 5/20 0.42
ERBB4 Q15303 2/20 0.42
EPHA2 P29317 4/20 0.41
KDR P35968 5/20 0.40
EPHB4 P54760 2/20 0.40
ROCK1 Q13464 2/20 0.40
CHEK2 O96017 1/20 0.40
PRKACA P17612 1/20 0.40
RPS6KA3 P51812 1/20 0.40
PAK1 Q13153 1/20 0.40
DYRK1A Q13627 1/20 0.40
PRKD2 Q9BZL6 1/20 0.40
SYK P43405 1/20 0.39
PRKD3 O94806 1/20 0.39
MET P08581 1/20 0.39
HDAC3 O15379 4/20 0.39
HDAC4 P56524 4/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL877966 0.91 ROCK2 (0.49) ROCK2EGFRERBB2ERBB4KDR
SCHEMBL877935 0.91 ROCK2 (0.56) ROCK2EGFRITKERBB2ERBB4
SCHEMBL877065 0.91 EGFR (0.45) ROCK2EGFRITKERBB2ERBB4
SCHEMBL876565 0.90 PRKD3 (0.48) ROCK2EGFRITKERBB2ERBB4
SCHEMBL877430 0.89 ERBB2 (0.47) ROCK2EGFRITKERBB2ERBB4
SCHEMBL882747 0.86 ROCK2 (0.47) ROCK2EGFRITKERBB2ERBB4
SCHEMBL877683 0.86 EGFR (0.44) ROCK2EGFRITKERBB2ERBB4
SCHEMBL10220363 0.86 ROCK2 (0.56) ROCK2EGFRITKERBB2ERBB4
SCHEMBL878170 0.85 EGFR (0.47) ROCK2EGFRITKROCK1CHEK2
SCHEMBL3793035 0.84 ROCK2 (0.63) ROCK2EGFRITKEPHA2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012040499-A2 METABOLIC INHIBITORS SURFACE LOGIX, INC. (US) 2012-03-29 WO disclosed
WO-2008054599-A2 RHO KINASE INHIBITORS SURFACE LOGIX, INC. (US) 2008-05-08 WO disclosed
EP-1865958-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS Surface Logix, Inc. (US) 2007-12-19 EP disclosed
WO-2006105081-A2 PHARMACOKINETICALLY IMPROVED COMPOUNDS SURFACE LOGIX, INC. (US) 2006-10-05 WO disclosed