Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.56 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774457 | 1.00 | SPHK1 (0.56) | SPHK1SPHK2KDM4EMEN1USP2 | |
| SCHEMBL8774673 | 0.96 | SPHK1 (0.50) | SPHK1SPHK2 | |
| SCHEMBL8774682 | 0.96 | SPHK1 (0.50) | SPHK1SPHK2 | |
| SCHEMBL8774408 | 0.91 | SPHK1 (0.43) | SPHK1SPHK2 | |
| SCHEMBL8774396 | 0.91 | SPHK1 (0.43) | SPHK1SPHK2 | |
| SCHEMBL8774920 | 0.86 | SPHK1 (0.49) | SPHK1SPHK2MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8774056 | 0.85 | DRD2 (0.38) | SPHK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL8774047 | 0.85 | DRD2 (0.38) | SPHK1KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL8774780 | 0.83 | SPHK1 (0.46) | SPHK1SPHK2MAPTRAB9A | |
| SCHEMBL8774791 | 0.83 | SPHK1 (0.46) | SPHK1SPHK2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |