Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774396 | 1.00 | SPHK1 (0.43) | SPHK1DRD2SPHK2ACACB | |
| SCHEMBL8774673 | 0.92 | SPHK1 (0.50) | SPHK1DRD2SPHK2 | |
| SCHEMBL8774682 | 0.92 | SPHK1 (0.50) | SPHK1DRD2SPHK2 | |
| SCHEMBL8774446 | 0.91 | SPHK1 (0.56) | SPHK1SPHK2 | |
| SCHEMBL8774457 | 0.91 | SPHK1 (0.56) | SPHK1SPHK2 | |
| SCHEMBL8774047 | 0.89 | DRD2 (0.38) | SPHK1DRD2 | |
| SCHEMBL8774056 | 0.89 | DRD2 (0.38) | SPHK1DRD2 | |
| SCHEMBL8774872 | 0.85 | MAOA (0.38) | SPHK1DRD2SPHK2 | |
| SCHEMBL8774879 | 0.85 | MAOA (0.38) | SPHK1DRD2SPHK2 | |
| SCHEMBL8774450 | 0.82 | SPHK1 (0.36) | SPHK1DRD2SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |