Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774047 | 1.00 | DRD2 (0.38) | DRD2LSSSPHK1MAPTEGLN1 | |
| SCHEMBL8774396 | 0.89 | SPHK1 (0.43) | DRD2SPHK1 | |
| SCHEMBL8774408 | 0.89 | SPHK1 (0.43) | DRD2SPHK1 | |
| SCHEMBL8774673 | 0.86 | SPHK1 (0.50) | DRD2SPHK1 | |
| SCHEMBL8774682 | 0.86 | SPHK1 (0.50) | DRD2SPHK1 | |
| SCHEMBL8774446 | 0.85 | SPHK1 (0.56) | SPHK1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL8774457 | 0.85 | SPHK1 (0.56) | SPHK1MAPTALDH1A1KDM4EGAA | |
| SCHEMBL8774896 | 0.83 | CYP2C9 (0.35) | DRD2LSSSPHK1MAPTALDH1A1 | |
| SCHEMBL8774886 | 0.83 | CYP2C9 (0.35) | DRD2LSSSPHK1MAPTALDH1A1 | |
| SCHEMBL7906713 | 0.82 | KDM4E (0.40) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |