Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 12/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774397 | 0.94 | NPC1 (0.47) | ACACBMCHR1ALDH1A1LMNANPC1 | |
| SCHEMBL8774773 | 0.92 | ALDH1A1 (0.50) | ACACBMCHR1ALDH1A1LMNANPC1 | |
| SCHEMBL8774402 | 0.88 | ALDH1A1 (0.51) | ACACBMCHR1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1007760 | 0.83 | ALDH1A1 (0.42) | ACACBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL8774695 | 0.81 | FFAR1 (0.43) | ACACBMCHR1ALDH1A1NPSR1 | |
| SCHEMBL9154082 | 0.80 | FFAR1 (0.48) | ACACBMCHR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774556 | 0.80 | EGLN1 (0.47) | ACACBALDH1A1LMNAPOLBNPSR1 | |
| SCHEMBL8774496 | 0.79 | RAB9A (0.49) | ACACBALDH1A1LMNANPC1RAB9A | |
| SCHEMBL3434851 | 0.79 | ACACB (0.57) | ACACBMCHR1L3MBTL1 | |
| SCHEMBL16706066 | 0.79 | ACACB (0.57) | ACACBMCHR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |