Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774695 | 0.88 | FFAR1 (0.43) | EGLN1TDP1FFAR1ACACBALDH1A1 | |
| SCHEMBL8774593 | 0.85 | FFAR1 (0.41) | EGLN1TDP1FFAR1L3MBTL1ACACB | |
| SCHEMBL8774237 | 0.84 | HSD17B10 (0.42) | FFAR1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL8774402 | 0.83 | ALDH1A1 (0.51) | ACACBALDH1A1LMNAPOLB | |
| SCHEMBL8774497 | 0.80 | ACACB (0.43) | L3MBTL1ACACBALDH1A1NPSR1LMNA | |
| SCHEMBL8774397 | 0.80 | NPC1 (0.47) | L3MBTL1ACACBALDH1A1LMNAPOLB | |
| SCHEMBL9158538 | 0.78 | FFAR1 (0.59) | EGLN1TDP1CYP2A6FFAR1L3MBTL1 | |
| SCHEMBL8774773 | 0.78 | ALDH1A1 (0.50) | L3MBTL1ACACBALDH1A1LMNAPOLB | |
| SCHEMBL8774742 | 0.77 | CHRNB2 (0.36) | EGLN1TDP1FFAR1ACACB | |
| SCHEMBL8774736 | 0.77 | CHRNB2 (0.36) | EGLN1TDP1FFAR1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |