Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774414 | 0.90 | TRPV3 (0.32) | TRPV3IDH1 | |
| SCHEMBL8774622 | 0.89 | TRPV3 (0.35) | TRPV3SCN5ASCN9A | |
| SCHEMBL8774099 | 0.88 | GAA (0.31) | — | |
| SCHEMBL8774050 | 0.87 | GAA (0.34) | — | |
| SCHEMBL8775030 | 0.86 | GAA (0.35) | — | |
| SCHEMBL9253040 | 0.84 | TRPV3 (0.33) | TRPV3 | |
| SCHEMBL9158982 | 0.81 | TRPV3 (0.32) | TRPV3 | |
| SCHEMBL8774515 | 0.81 | TRPV3 (0.39) | TRPV3APP | |
| SCHEMBL8774527 | 0.81 | TRPV3 (0.39) | TRPV3APP | |
| SCHEMBL8775149 | 0.80 | SLC6A2 (0.32) | TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |