Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775015 | 1.00 | EGLN1 (0.42) | EGLN1METAP2CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL8774798 | 0.88 | FEN1 (0.40) | EGLN1 | |
| SCHEMBL8775052 | 0.86 | RAB9A (0.48) | CYP17A1CYP11B1CYP11B2TP53NPC1 | |
| SCHEMBL8774871 | 0.86 | RAB9A (0.48) | CYP17A1CYP11B1CYP11B2TP53NPC1 | |
| SCHEMBL8774132 | 0.85 | NPC1 (0.40) | EGLN1METAP2CYP17A1CYP11B1TP53 | |
| SCHEMBL8774800 | 0.83 | RARB (0.49) | TP53NPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL8774086 | 0.83 | RARB (0.49) | TP53NPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL8774269 | 0.82 | RARB (0.55) | NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774355 | 0.82 | RARB (0.55) | NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774259 | 0.81 | FEN1 (0.40) | NPC1RAB9ASMN1; SMN2GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |