Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 10/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774259 | 0.92 | FEN1 (0.40) | FEN1ALOX5APPDE3BPDE3AUSP7 | |
| SCHEMBL8774168 | 0.89 | NPC1 (0.42) | FEN1ALOX5APCHKARARB | |
| SCHEMBL8774747 | 0.88 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL8775015 | 0.88 | EGLN1 (0.42) | EGLN1 | |
| SCHEMBL8774482 | 0.86 | RARB (0.46) | FEN1ALOX5APRARB | |
| SCHEMBL8774382 | 0.85 | RARB (0.51) | RARB | |
| SCHEMBL8774508 | 0.84 | RARB (0.53) | RARB | |
| SCHEMBL8774834 | 0.84 | RARB (0.53) | RARB | |
| SCHEMBL9156736 | 0.84 | PDE3B (0.42) | FEN1ALOX5APCHKARARBPDE3B | |
| SCHEMBL19007861 | 0.82 | CHKA (0.44) | CHKARARBGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |