SCHEMBL8774872

SCHEMBL8774872

CCCc1ccc([C@H]2CC[C@H](CCc3cnc(Cl)c(Cl)c3)CC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
SPHK1 Q9NYA1 11/20 0.38
CYP2C9 P11712 1/20 0.37
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
MEN1 O00255 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
DRD2 P14416 1/20 0.35
SPHK2 Q9NRA0 7/20 0.34
ESR2 Q92731 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8774879 1.00 MAOA (0.38) MAOAMAOBSPHK1CYP2C9ALDH1A1
SCHEMBL8774647 0.93 SPHK1 (0.44) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL8774636 0.93 SPHK1 (0.44) SPHK1CYP2C9ALDH1A1LMNAMAPT
SCHEMBL8774920 0.92 SPHK1 (0.49) SPHK1CYP2C9MAPTSPHK2
SCHEMBL8774886 0.92 CYP2C9 (0.35) MAOBSPHK1CYP2C9ALDH1A1LMNA
SCHEMBL8774896 0.92 CYP2C9 (0.35) MAOBSPHK1CYP2C9ALDH1A1LMNA
SCHEMBL8774408 0.85 SPHK1 (0.43) SPHK1DRD2SPHK2
SCHEMBL8774396 0.85 SPHK1 (0.43) SPHK1DRD2SPHK2
SCHEMBL9161223 0.84 CYP2C9 (0.42) MAOAMAOBSPHK1CYP2C9ALDH1A1
SCHEMBL9161214 0.84 CYP2C9 (0.42) MAOAMAOBSPHK1CYP2C9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0519370-B1 Heterocyclic derivatives MERCK PATENT GMBH (DE) 1997-11-05 EP disclosed
EP-0519370-A2 Heterocyclic derivatives MERCK PATENT GmbH (DE) 1992-12-23 EP disclosed