Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | EIF4A1 | P60842 | 2/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774909 | 0.96 | HSD17B10 (0.48) | TSHRHSD17B10FFAR1RARBRARA | |
| SCHEMBL8774821 | 0.96 | FFAR1 (0.43) | TSHRHSD17B10FFAR1RARBRARA | |
| SCHEMBL8774374 | 0.92 | FFAR1 (0.42) | TSHRHSD17B10FFAR1RARBRARA | |
| SCHEMBL8774994 | 0.92 | FFAR1 (0.42) | TSHRHSD17B10FFAR1RARBRARA | |
| SCHEMBL8774302 | 0.91 | HSD17B10 (0.43) | TSHRHSD17B10FFAR1RARBRARA | |
| SCHEMBL8774295 | 0.88 | FFAR1 (0.44) | FFAR1S1PR1 | |
| SCHEMBL8774750 | 0.87 | FFAR1 (0.38) | FFAR1RARBRARARARGNPC1 | |
| SCHEMBL8775170 | 0.85 | CYP2D6 (0.46) | HSD17B10RARBRARANPC1RAB9A | |
| SCHEMBL8774468 | 0.85 | FFAR1 (0.40) | TSHRHSD17B10FFAR1PTPN11PTPRO | |
| SCHEMBL31633923 | 0.84 | TSHR (0.47) | TSHRHSD17B10FFAR1RARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |