Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 6/20 | 0.40 |
| ▸ | SKP1 | P63208 | 6/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 6/20 | 0.40 |
| ▸ | ME2 | P23368 | 2/20 | 0.39 |
| ▸ | ME1 | P48163 | 2/20 | 0.39 |
| ▸ | ME3 | Q16798 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 2/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25666898 | 0.84 | MAPT (0.44) | HRH3KMOHCAR2 | |
| SCHEMBL28630760 | 0.83 | HDAC3 (0.46) | HRH3 | |
| SCHEMBL30855580 | 0.83 | MAPT (0.45) | HRH3KMOHCAR2 | |
| SCHEMBL14658665 | 0.83 | MAPT (0.45) | HRH3KMOHCAR2 | |
| SCHEMBL8291820 | 0.80 | AKR1C3 (0.43) | CKS1BSKP1SKP2ME2ME1 | |
| SCHEMBL29907656 | 0.80 | KMO (0.60) | KMOAKR1C3 | |
| SCHEMBL10241318 | 0.80 | HDAC3 (0.52) | KMO | |
| SCHEMBL29631957 | 0.80 | PANK3 (0.55) | CKS1BSKP1SKP2ME2ME1 | |
| SCHEMBL322646 | 0.80 | KMO (0.60) | KMOAKR1C3 | |
| SCHEMBL876797 | 0.80 | CKS1B (0.59) | HRH3CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809321-B1 | PHENYL-C-OXADIAZOLE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE PRODUCTION FOR USE IN COMBINATION THERAPY | BOEHRINGER INGELHEIM INT (DE) | 2016-11-09 | — | — | EP | disclosed |
| EP-2606045-B1 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2016-01-06 | — | — | EP | disclosed |
| WO-2013113799-A1 | PHENYL -C-OXADIAZOLE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE PRODUCTION COMBINATION THERAPY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-08 | — | — | WO | disclosed |
| EP-2619197-A1 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | Boehringer Ingelheim International GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040139-A1 | OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-03-29 | — | — | WO | disclosed |