Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SPNS2 | Q8IVW8 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775034 | 1.00 | RARB (0.40) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774058 | 0.99 | RARB (0.38) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774053 | 0.99 | RARB (0.38) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774103 | 0.95 | GPR84 (0.38) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774107 | 0.95 | GPR84 (0.38) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774424 | 0.90 | MAOB (0.38) | RARBMAOBMAOAGPR84FFAR4 | |
| SCHEMBL8774417 | 0.90 | MAOB (0.38) | RARBMAOBMAOAGPR84FFAR4 | |
| SCHEMBL8774400 | 0.89 | RARB (0.36) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774407 | 0.89 | RARB (0.36) | RARBGAAMAPTCYP3A4CYP2C8 | |
| SCHEMBL8774623 | 0.88 | GPR84 (0.36) | MAOBMAOAGPR84FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |