Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | STS | P08842 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 8/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356258 | 1.00 | HSD17B10 (0.52) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL8775817 | 0.90 | ESR1 (0.58) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL1415037 | 0.80 | CA2 (0.35) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL13645679 | 0.79 | HSD17B10 (0.49) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL6541320 | 0.76 | HSD17B10 (0.69) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL6541316 | 0.76 | HSD17B10 (0.69) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL6854847 | 0.75 | ESR1 (0.64) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL6854850 | 0.75 | ESR1 (0.64) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL9144315 | 0.75 | ESR1 (0.64) | HSD17B10MAPK1TSHRAKR1C3LMNA | |
| SCHEMBL7923895 | 0.75 | ESR1 (0.61) | HSD17B10TSHRLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719276-B1 | ORALLY ACTIVE DERIVATIVES OF 1,3,5(10)-ESTRATRIENE | US HEALTH (US) | 1997-11-26 | — | — | EP | claimed |
| WO-1995007925-A1 | ORALLY ACTIVE DERIVATIVES OF 1,3,5(10)-ESTRATRIENE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-03-23 | — | — | WO | claimed |