Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 8/20 | 0.44 |
| ▸ | CTSS | P25774 | 7/20 | 0.44 |
| ▸ | CTSB | P07858 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | PREP | P48147 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL51947 | 0.90 | CTSL (0.42) | CTSLCTSSCTSBCYP1A2CYP3A4 | |
| SCHEMBL86626 | 0.81 | CTSB (0.46) | CTSLCTSSCTSBCYP1A2NPC1 | |
| SCHEMBL52527 | 0.81 | CTSB (0.46) | CTSLCTSSCTSBCYP1A2NPC1 | |
| SCHEMBL52526 | 0.81 | CTSB (0.46) | CTSLCTSSCTSBCYP1A2NPC1 | |
| SCHEMBL1018180 | 0.77 | CTSL (0.57) | CTSLCTSSCTSBMAPK1SMN1; SMN2 | |
| SCHEMBL87370 | 0.75 | CTSS (0.51) | CTSLCTSSCTSBCTSKPREP | |
| SCHEMBL13691658 | 0.74 | CTSB (0.39) | CTSLCTSSCTSBCYP1A2NPC1 | |
| SCHEMBL9900827 | 0.74 | CTSL (0.63) | CTSLCTSSCTSBCTSKPREP | |
| SCHEMBL51969 | 0.73 | CTSL (0.40) | CTSLCTSSCTSBCYP1A2NPC1 | |
| SCHEMBL51968 | 0.73 | CTSL (0.40) | CTSLCTSSCTSBCYP1A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | CTSL 3453/4885CTSS 3030/4885CTSB 2999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.