SCHEMBL8776678

SCHEMBL8776678

C=CC(CC)Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.46
TAAR1 Q96RJ0 5/20 0.43
SIGMAR1 Q99720 5/20 0.43
SLC6A2 P23975 2/20 0.43
MAOA P21397 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
CYP2A6 P11509 1/20 0.43
ADORA2A P29274 1/20 0.43
ADORA1 P30542 1/20 0.43
EPHX1 P07099 2/20 0.41
TP53 P04637 1/20 0.41
SLC18A2 Q05940 1/20 0.41
CYP2D6 P10635 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14690339 0.81 CSNK1E (0.44) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL9427101 0.81 TRPA1 (0.47) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL3669842 0.80 ALDH1A1 (0.42) TRPA1SLC6A4TP53MEN1KMT2A
SCHEMBL8776657 0.80 TRPA1 (0.43) TRPA1TAAR1MAOA
SCHEMBL997694 0.80 MC4R (0.47) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL27842054 0.80 SIGMAR1 (0.44) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL15242552 0.79 ANPEP (0.50) TAAR1SIGMAR1SLC6A2MAOASLC6A4
SCHEMBL6569511 0.79 TRPA1 (0.48) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL1774298 0.79 TAAR1 (0.48) TRPA1TAAR1SIGMAR1SLC6A2MAOA
SCHEMBL27783457 0.79 TRPA1 (0.46) TRPA1TAAR1SIGMAR1SLC6A2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0213633-A1 Alcohols and esters from the reaction of butadiene with magnesium and alkyl halogenides, their production and their use as perfumes Consortium für elektrochemische Industrie GmbH (DE) 1987-03-11 EP claimed
EP-0809647-A1 CHIRAL ORGANOMETALLIC COMPOUNDS ZENECA LIMITED (GB) 1997-12-03 EP disclosed
WO-1996025420-A1 CHIRAL ORGANOMETALLIC COMPOUNDS ZENECA LIMITED (GB) 1996-08-22 WO disclosed
EP-0213633-B1 ALCOHOLS AND ESTERS FROM THE REACTION OF BUTADIENE WITH MAGNESIUM AND ALKYL HALOGENIDES, THEIR PRODUCTION AND THEIR USE AS PERFUMES Consortium für elektrochemische Industrie GmbH (DE) 1989-01-18 EP disclosed