SCHEMBL8776715

SCHEMBL8776715

c1ccc(CC2CCN(N3CC[N]CC3)CC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 3/20 0.57
CARM1 Q86X55 2/20 0.53
PRMT6 Q96LA8 2/20 0.53
PRMT3 O60678 1/20 0.53
PRMT1 Q99873 1/20 0.53
PRMT8 Q9NR22 1/20 0.53
GRIN2B Q13224 2/20 0.51
MGLL Q99685 1/20 0.51
ALDH1A1 P00352 2/20 0.51
SIGMAR1 Q99720 2/20 0.50
TSHR P16473 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL42600 0.81 GBA1 (0.59) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL8101596 0.81 CCR3 (0.59) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL8481226 0.79 GBA1 (0.68) CCR3CARM1PRMT6PRMT3PRMT1
Hydrochloric Acid SCHEMBL8483895 0.78 GBA1 (0.66) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL3765344 0.76 CCR3 (0.57) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL2027845 0.74 GBA1 (0.71) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL674276 0.74 GBA1 (0.71) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL3822693 0.74 CCR3 (0.65) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL13884225 0.74 CCR3 (0.65) CCR3CARM1PRMT6PRMT3PRMT1
SCHEMBL8011157 0.74 CCR3 (0.65) CCR3CARM1PRMT6PRMT3PRMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0799202-A1 PIPERAZINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME, THEIR USE AND PROCESS FOR PREPARING THE SAME Dr. Karl Thomae GmbH (DE) 1997-10-08 EP disclosed