Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14398428 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL3605491 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL8776712 | 0.73 | ALDH1A1 (0.53) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL2965820 | 0.71 | ALDH1A1 (0.49) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL12071486 | 0.71 | SLC22A12 (1.00) | MEN1KMT2ASLC22A12 | |
| SCHEMBL3157902 | 0.70 | SLC22A12 (0.51) | ALDH1A1MAPTHSD17B10SLC22A12CYP1A2 | |
| SCHEMBL30697700 | 0.70 | HPGD (0.45) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL26121636 | 0.70 | HPGD (0.45) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL15897470 | 0.70 | MAPT (0.50) | ALDH1A1MAPTMEN1KMT2ARAB9A | |
| SCHEMBL16297352 | 0.69 | TP53 (0.46) | ALDH1A1MAPTMEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |