Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4864675 | 0.82 | KMT2A (0.51) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL10041973 | 0.79 | POLB (0.51) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL266382 | 0.79 | POLB (0.51) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL10050934 | 0.79 | POLB (0.51) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL5918159 | 0.77 | MEN1 (0.42) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL11082940 | 0.75 | MEN1 (0.41) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL11082943 | 0.75 | MEN1 (0.41) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL27425745 | 0.73 | MEN1 (0.47) | KMT2AMEN1HPGDMAPTTSHR | |
| SCHEMBL14253816 | 0.72 | ALDH1A1 (0.41) | KMT2AMEN1HPGDPOLBMAPT | |
| SCHEMBL11292055 | 0.72 | KMT2A (0.66) | KMT2AMEN1MAPTPTGS2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |