Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 3/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777039 | 0.80 | NR1H3 (0.53) | ADORA3ADORA2ANR1H3NR1H2L3MBTL1 | |
| SCHEMBL5465021 | 0.77 | KIT (0.60) | ADORA3ADORA2AL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL10491139 | 0.75 | DPP4 (0.68) | NR1H3NR1H2L3MBTL1DPP4ANPEP | |
| SCHEMBL30452106 | 0.74 | KDM4E (0.57) | L3MBTL1SMN1; SMN2TP53KDM4EMAPK1 | |
| SCHEMBL7689616 | 0.73 | NR1H3 (0.71) | NR1H3NR1H2 | |
| SCHEMBL21221092 | 0.72 | ADORA3 (0.51) | ADORA3ADORA2AL3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL19397816 | 0.71 | DPP4 (0.71) | L3MBTL1DPP4ANPEPKDM4EMAPK1 | |
| SCHEMBL5478760 | 0.70 | PTPRC (0.61) | L3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL29002768 | 0.70 | MEN1 (0.59) | ADORA3ADORA2AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL9394556 | 0.69 | KDM4E (0.51) | ADORA3ADORA2ANR1H3NR1H2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A9 | SUBSTITUTED IMIDES AS TNF INHIBITORS | — | 1996-09-26 | — | — | WO | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |