Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 6/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777038 | 0.80 | HSP90AA1 (0.50) | NR1H3NR1H2KDM4EMAPK1L3MBTL1 | |
| SCHEMBL6156837 | 0.74 | SCN2A (0.57) | NR1H3NR1H2MEN1KMT2ASCN2A | |
| SCHEMBL7689616 | 0.74 | NR1H3 (0.71) | NR1H3NR1H2MEN1KMT2A | |
| SCHEMBL17059033 | 0.74 | KMT2A (0.56) | NR1H3NR1H2MEN1KMT2AKDM4E | |
| SCHEMBL17950974 | 0.74 | KMT2A (0.60) | NR1H3MEN1KMT2AKDM4E | |
| SCHEMBL30758650 | 0.72 | KMT2A (0.76) | NR1H3NR1H2MEN1KMT2ASCN2A | |
| SCHEMBL29168849 | 0.72 | KMT2A (0.76) | NR1H3NR1H2MEN1KMT2ASCN2A | |
| SCHEMBL5465021 | 0.72 | KIT (0.60) | MEN1KMT2AKDM4EL3MBTL1ADORA3 | |
| SCHEMBL6679321 | 0.72 | KMT2A (0.54) | NR1H3NR1H2MEN1KMT2ASCN2A | |
| SCHEMBL6676139 | 0.72 | MEN1 (0.68) | NR1H3NR1H2MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800514-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020926-A9 | SUBSTITUTED IMIDES AS TNF INHIBITORS | — | 1996-09-26 | — | — | WO | disclosed |
| WO-1996020926-A1 | SUBSTITUTED IMIDES AS TNF INHIBITORS | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |