Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311971 | 0.90 | HRH1 (0.77) | HRH1TAAR1HTR2ACXCL8CYP2A6 | |
| SCHEMBL5950358 | 0.85 | SLC6A2 (0.50) | HRH1SLC6A2SLC6A4CXCL8 | |
| SCHEMBL8777062 | 0.84 | HRH1 (0.44) | HRH1TAAR1SLC6A2SLC6A4CXCL8 | |
| SCHEMBL11100370 | 0.84 | HRH1 (0.44) | HRH1TAAR1SLC6A2SLC6A4CXCL8 | |
| SCHEMBL10862161 | 0.79 | TAAR1 (0.67) | HRH1TAAR1HTR2AMPOCYP1A2 | |
| SCHEMBL2356168 | 0.78 | CXCL8 (0.64) | SLC6A2SLC6A4CXCL8 | |
| SCHEMBL1569927 | 0.78 | HRH1 (1.00) | HRH1TAAR1SLC6A2SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL10862159 | 0.77 | TAAR1 (0.64) | HRH1TAAR1HTR2AMPOCYP1A2 | |
| SCHEMBL6236000 | 0.77 | HRH1 (0.48) | HRH1TAAR1SLC6A2SLC6A4CXCL8 | |
| SCHEMBL8777076 | 0.77 | HRH1 (0.50) | HRH1TAAR1SLC6A2SLC6A4CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800513-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5605932-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5536868-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |
| WO-1996020921-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |
| US-5481020-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |