Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236000 | 0.90 | HRH1 (0.48) | HRH1TAAR1CXCL8AOC3SLC6A4 | |
| SCHEMBL6319190 | 0.85 | HRH1 (0.52) | HRH1TAAR1DPP4CXCL8PNMT | |
| SCHEMBL8777062 | 0.84 | HRH1 (0.44) | HRH1TAAR1DPP4CXCL8PNMT | |
| SCHEMBL11100370 | 0.84 | HRH1 (0.44) | HRH1TAAR1CXCL8SLC6A4SLC6A2 | |
| SCHEMBL28327254 | 0.79 | TAAR1 (0.52) | TAAR1AOC3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL632593 | 0.79 | DPP4 (0.48) | TAAR1DPP4PNMTTDP1 | |
| SCHEMBL1067253 | 0.78 | HRH1 (0.67) | HRH1SLC6A4SLC6A2TDP1SLC6A3 | |
| SCHEMBL17024100 | 0.78 | HRH1 (0.46) | HRH1TAAR1CXCL8SLC6A4SLC6A2 | |
| SCHEMBL5694864 | 0.78 | TAAR1 (0.44) | HRH1TAAR1AOC3TDP1HTR1A | |
| SCHEMBL6311971 | 0.77 | HRH1 (0.77) | HRH1TAAR1CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800513-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5605932-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5536868-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |
| WO-1996020921-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |
| US-5481020-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |