Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440523 | 0.84 | P2RX3 (0.42) | P2RX3P2RX2ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL2778070 | 0.80 | PNMT (0.41) | TAAR1 | |
| SCHEMBL27995634 | 0.80 | PNMT (0.41) | TAAR1 | |
| SCHEMBL6319190 | 0.80 | HRH1 (0.52) | HRH1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8777062 | 0.74 | HRH1 (0.44) | HRH1TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24762924 | 0.73 | SMN1; SMN2 (0.47) | HRH1TAAR1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL2356142 | 0.73 | SLC6A4 (0.49) | ALDH1A1SLC6A2SLC6A4L3MBTL1RIPK1 | |
| SCHEMBL14047087 | 0.72 | TAAR1 (0.38) | TAAR1ALDH1A1 | |
| SCHEMBL26921471 | 0.72 | LMNA (0.52) | ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL2351750 | 0.72 | SLC6A2 (0.46) | P2RX3P2RX2ALDH1A1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800513-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5605932-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5536868-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-07-16 | — | — | US | disclosed |
| WO-1996020921-A1 | OPIATE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |
| US-5481020-A | Opiate receptor ligands | CHIRON CORPORATION (US) | 1996-01-02 | — | — | US | disclosed |