Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.49 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530938 | 0.98 | ACHE (0.50) | ACHESMN1; SMN2APEX1LMNACHRM5 | |
| Hydrochloric Acid SCHEMBL233973 | 0.89 | APEX1 (0.41) | ACHESMN1; SMN2APEX1ATMMAPT | |
| SCHEMBL1628096 | 0.86 | APEX1 (0.42) | ACHESMN1; SMN2APEX1LMNAATM | |
| SCHEMBL25544701 | 0.86 | APEX1 (0.42) | ACHESMN1; SMN2APEX1LMNAATM | |
| Hydrochloric Acid SCHEMBL27998931 | 0.81 | ACHE (0.47) | ACHESMN1; SMN2APEX1LMNABLM | |
| Sulfuric Acid SCHEMBL25230184 | 0.80 | APEX1 (0.42) | ACHESMN1; SMN2APEX1ATMMAPT | |
| SCHEMBL19971707 | 0.80 | ACHE (0.38) | ACHESMN1; SMN2APEX1ATMKMT2A | |
| SCHEMBL22187119 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2APEX1MAPTALDH1A1KMT2A | |
| SCHEMBL14642043 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2APEX1MAPTALDH1A1KMT2A | |
| SCHEMBL20598562 | 0.78 | SMN1; SMN2 (0.38) | ACHESMN1; SMN2APEX1LMNACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812956-A1 | HIGH PERFORMANCE PAPER AND PROCESS FOR PRODUCING THE SAME | Oji Paper Co., Ltd. (JP) | 1997-12-17 | — | — | EP | disclosed |