Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9597330 | 0.93 | ACHE (0.49) | ACHE | |
| SCHEMBL4728528 | 0.88 | ALOX5 (0.45) | ALOX5EPHX2TNFACHEKCNT1 | |
| SCHEMBL9088740 | 0.85 | ALOX5 (0.46) | ALOX5EPHX2TNFACHEKCNT1 | |
| SCHEMBL9085805 | 0.84 | ALOX5 (0.42) | BRD4ALOX5EPHX2TNFACHE | |
| SCHEMBL9598417 | 0.84 | HDAC1 (0.56) | ACHE | |
| SCHEMBL9029836 | 0.81 | HDAC1 (0.53) | ACHE | |
| Methane SCHEMBL27429811 | 0.81 | TNF (0.46) | BRD4ALOX5EPHX2TNFACHE | |
| SCHEMBL9597233 | 0.80 | HDAC1 (0.52) | ACHE | |
| SCHEMBL8777937 | 0.80 | ALOX5 (0.55) | ALOX5EPHX2KCNT1 | |
| SCHEMBL9089073 | 0.79 | HDAC1 (0.43) | ALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651743-B1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5541218-A | Indolinyl N-hydroxyurea and N-hydroxamic acid derivatives as lipoxygenase inhibitors | PFIZER INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0651743-A1 | INDOLINYL N-HYDROXYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002459-A1 | INDOLINYL N-HYDROZYUREA AND N-HYDROXAMIC ACID DERIVATIVES AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-02-03 | — | — | WO | disclosed |